Lysosomal hydrolases have long been known to be responsible for the degradation of
different substrates in the cell. These acid hydrolases are synthesized in the rough
endoplasmic reticulum and transported through the Golgi apparatus to the trans-Golgi
network (TGN). From there, they are delivered to endosomal/lysosomal compartments,
where they finally become active due to the acidic pH characteristic of the lysosomal
compartment. The majority of the enzymes leave the TGN after modification with mannose-6 …