Hormonal control of Leydig cell differentiation.
MP Hardy, SJ Gelber, ZF Zhou, TM Penning… - Annals of the New …, 1991 - europepmc.org
MP Hardy, SJ Gelber, ZF Zhou, TM Penning, JW Ricigliano, VK Ganjam, D Nonneman…
Annals of the New York Academy of Sciences, 1991•europepmc.orgLeydig cell progenitors contain significant concentrations of androgen receptors. When the
metabolism of DHT to 3 alpha-DIOL is blocked, DHT stimulates testosterone production by
Leydig cell progenitors, most probably via an androgen receptor dependent mechanism.
Rapid metabolism by 3 alpha-HSD may limit the potency of exogenous DHT to stimulate
differentiation of Leydig cell progenitors in vitro. Insulin-like growth factor-I enhances
androgen production by purified immature Leydig cells. The elevated sensitivity of immature …
metabolism of DHT to 3 alpha-DIOL is blocked, DHT stimulates testosterone production by
Leydig cell progenitors, most probably via an androgen receptor dependent mechanism.
Rapid metabolism by 3 alpha-HSD may limit the potency of exogenous DHT to stimulate
differentiation of Leydig cell progenitors in vitro. Insulin-like growth factor-I enhances
androgen production by purified immature Leydig cells. The elevated sensitivity of immature …
Leydig cell progenitors contain significant concentrations of androgen receptors. When the metabolism of DHT to 3 alpha-DIOL is blocked, DHT stimulates testosterone production by Leydig cell progenitors, most probably via an androgen receptor dependent mechanism. Rapid metabolism by 3 alpha-HSD may limit the potency of exogenous DHT to stimulate differentiation of Leydig cell progenitors in vitro. Insulin-like growth factor-I enhances androgen production by purified immature Leydig cells. The elevated sensitivity of immature Leydig cells versus adult Leydig cells to IGF-I stimulation indicates that this peptide hormone has a role in their differentiation during puberty.
europepmc.org