Estrogen dependent signaling in reproductive tissues–a role for estrogen receptors and estrogen related receptors
DA Gibson, PTK Saunders - Molecular and cellular endocrinology, 2012 - Elsevier
Molecular and cellular endocrinology, 2012•Elsevier
Estrogens play a fundamental role in the development and normal physiological function of
multiple tissue systems and have been implicated in the ontogeny of cancers. The biological
effects of estrogens are classically mediated via interaction with cognate nuclear receptors.
The relative expression of ER subtypes/variants varies between cells within different tissues
and this alters the response to natural and synthetic ligands. This review focuses on the role
of estrogen and estrogen related receptors in reproductive tissues.
multiple tissue systems and have been implicated in the ontogeny of cancers. The biological
effects of estrogens are classically mediated via interaction with cognate nuclear receptors.
The relative expression of ER subtypes/variants varies between cells within different tissues
and this alters the response to natural and synthetic ligands. This review focuses on the role
of estrogen and estrogen related receptors in reproductive tissues.
Estrogens play a fundamental role in the development and normal physiological function of multiple tissue systems and have been implicated in the ontogeny of cancers. The biological effects of estrogens are classically mediated via interaction with cognate nuclear receptors. The relative expression of ER subtypes/variants varies between cells within different tissues and this alters the response to natural and synthetic ligands. This review focuses on the role of estrogen and estrogen related receptors in reproductive tissues.
Elsevier