Evidence for distinct leptomeningeal cell-dependent paracrine and EGF-linked autocrine regulatory pathways for suppression of fibrillar collagens in astrocytes
N Heck, J Garwood, A Dobbertin, V Calco… - Molecular and Cellular …, 2007 - Elsevier
A unique and unresolved property of the central nervous system is that its extracellular
matrix lacks fibrillar elements. In the present report, we show that astrocytes secrete triple
helices of fibrillar collagens type I, III and V in culture, while no astroglial collagen
expression could be detected in vivo. We discovered two inhibitory mechanisms that could
underlie this apparent discrepancy. Thus, we uncover a strong inhibitory effect of meningeal
cells on astrocytic collagen expression in coculture assays. Furthermore, we present …
matrix lacks fibrillar elements. In the present report, we show that astrocytes secrete triple
helices of fibrillar collagens type I, III and V in culture, while no astroglial collagen
expression could be detected in vivo. We discovered two inhibitory mechanisms that could
underlie this apparent discrepancy. Thus, we uncover a strong inhibitory effect of meningeal
cells on astrocytic collagen expression in coculture assays. Furthermore, we present …
