[HTML][HTML] Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human
A critical role of progesterone (P) during early pregnancy is to induce differentiation of the
endometrial stromal cells into specialized decidual cells that support the development of the
implanting embryo. The P-induced signaling pathways that participate in the formation and
function of the decidual cells remain poorly understood. We report here that the expression
of the bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ
superfamily, is induced downstream of P action in the mouse uterine stroma during …
endometrial stromal cells into specialized decidual cells that support the development of the
implanting embryo. The P-induced signaling pathways that participate in the formation and
function of the decidual cells remain poorly understood. We report here that the expression
of the bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ
superfamily, is induced downstream of P action in the mouse uterine stroma during …