[HTML][HTML] Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis
Z Fang, S Yang, JP Lydon, F DeMayo, M Tamura… - Fertility and sterility, 2004 - Elsevier
OBJECTIVE: To determine the role of P and its nuclear receptor PR in the growth of ectopic
uterine tissue of mice with or without a disrupted PR gene. DESIGN: Animal study. SETTING:
Academic medical center. ANIMAL (S): Female wild-type (WT) and transgenic knockout mice
for P receptor (PRKO). INTERVENTION (S): Endometriosis was induced in the following
groups of ovariectomized adult mice:[1] untreated WT,[2] estradiol (E2)-treated WT,[3] P-
treated WT,[4] E2+ P-treated WT,[5] untreated PRKO,[6] E2-treated PRKO, and [7] E2+ P …
uterine tissue of mice with or without a disrupted PR gene. DESIGN: Animal study. SETTING:
Academic medical center. ANIMAL (S): Female wild-type (WT) and transgenic knockout mice
for P receptor (PRKO). INTERVENTION (S): Endometriosis was induced in the following
groups of ovariectomized adult mice:[1] untreated WT,[2] estradiol (E2)-treated WT,[3] P-
treated WT,[4] E2+ P-treated WT,[5] untreated PRKO,[6] E2-treated PRKO, and [7] E2+ P …