[HTML][HTML] Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary …
JA Schroeder, MC Thompson, MM Gardner… - Journal of Biological …, 2001 - ASBMB
MUC1 is a large (> 400 kDa), heavily glycosylated transmembrane protein that is aberrantly
expressed on greater than 90% of human breast carcinomas and subsequent metastases.
The precise function of MUC1 overexpression in tumorigenesis is unknown, although
various domains of MUC1 have been implicated in cell adhesion, cell signaling, and
immunoregulation. Stimulation of the MDA-MB-468 breast cancer line as well as mouse
mammary glands with epidermal growth factor results in the co-immunoprecipitation of …
expressed on greater than 90% of human breast carcinomas and subsequent metastases.
The precise function of MUC1 overexpression in tumorigenesis is unknown, although
various domains of MUC1 have been implicated in cell adhesion, cell signaling, and
immunoregulation. Stimulation of the MDA-MB-468 breast cancer line as well as mouse
mammary glands with epidermal growth factor results in the co-immunoprecipitation of …
