[HTML][HTML] Dynamic complexes of β2-adrenergic receptors with protein kinases and phosphatases and the role of gravin
Signals mediated by G-protein-linked receptors display agonist-induced attenuation and
recovery involving both protein kinases and phosphatases. The role of protein kinases and
phosphatases in agonist-induced attenuation and recovery of β-adrenergic receptors was
explored by two complementary approaches, antisense RNA suppression and co-
immunoprecipitation of target elements. Protein phosphatases 2A and 2B are associated
with the unstimulated receptor, the latter displaying a transient decrease followed by a 2-fold …
recovery involving both protein kinases and phosphatases. The role of protein kinases and
phosphatases in agonist-induced attenuation and recovery of β-adrenergic receptors was
explored by two complementary approaches, antisense RNA suppression and co-
immunoprecipitation of target elements. Protein phosphatases 2A and 2B are associated
with the unstimulated receptor, the latter displaying a transient decrease followed by a 2-fold …