The effect of erythromycin on gastric emptying is modified by physiological changes in the blood glucose concentration
Official journal of the American College of Gastroenterology| ACG, 1999•journals.lww.com
OBJECTIVE: The aim of this study was to determine whether variations in the blood glucose
concentration within the normal postprandial range affect the gastrokinetic action of
erythromycin. METHODS: Six healthy male volunteers, aged 20–33 yr underwent
measurements of gastric emptying on 2 separate days; blood glucose concentrations were
maintained at approximately 4 mmol/L (72 mg/dl) on 1 day and at 8 mmol/L (144 mg/dl) on
the other. The order of the two studies was randomized and they were separated by 4–7 …
concentration within the normal postprandial range affect the gastrokinetic action of
erythromycin. METHODS: Six healthy male volunteers, aged 20–33 yr underwent
measurements of gastric emptying on 2 separate days; blood glucose concentrations were
maintained at approximately 4 mmol/L (72 mg/dl) on 1 day and at 8 mmol/L (144 mg/dl) on
the other. The order of the two studies was randomized and they were separated by 4–7 …
Abstract
OBJECTIVE:
The aim of this study was to determine whether variations in the blood glucose concentration within the normal postprandial range affect the gastrokinetic action of erythromycin.
METHODS:
Six healthy male volunteers, aged 20–33 yr underwent measurements of gastric emptying on 2 separate days; blood glucose concentrations were maintained at approximately 4 mmol/L (72 mg/dl) on 1 day and at 8 mmol/L (144 mg/dl) on the other. The order of the two studies was randomized and they were separated by 4–7 days. On both days, erythromycin (3 mg/kg) was administered intravenously over 15 min immediately before consumption of 300 g minced beef labeled with 20 MBq 99m Tc-sulphur colloid chicken liver and 150 ml water labeled with 67 Ga-EDTA.
RESULTS:
Gastric emptying of solid (p< 0.05) and liquid (p< 0.0001) were slower at a blood glucose concentration of 8 mmol/L (144 mg/dl) when compared to 4 mmol/L (72 mg/dl). The slowing of gastric emptying was associated with greater retention of both solid and liquid in the proximal (p< 0.06) and distal (p< 0.01) stomach.
CONCLUSIONS:
After administration of erythromycin, gastric emptying and intragastric distribution of solids and liquids is influenced by physiological changes in the blood glucose concentration.
Lippincott Williams & Wilkins