The role of nitric oxide (NO) in the human pyloric sphincter.
R Tomita, K Tanjoh, S Fujisaki… - Hepato …, 1999 - europepmc.org
R Tomita, K Tanjoh, S Fujisaki, M Fukuzawa
Hepato-gastroenterology, 1999•europepmc.orgResults Cholinergic nerves were mainly involved in the regulation of enteric nerve
responses to EFS in the basal condition of the study, and NANC inhibitory nerves acted on
human pylorus. L-NNA concentration dependently inhibited the relaxation in response to
EFS in the human pylorus, and this inhibitory effect in the pylorus was reversed by L-
arginine. Conclusions These findings suggest that the cholinergic/adrenergic and NANC
inhibitory nerves play important roles in regulating contraction and relaxation of the human …
responses to EFS in the basal condition of the study, and NANC inhibitory nerves acted on
human pylorus. L-NNA concentration dependently inhibited the relaxation in response to
EFS in the human pylorus, and this inhibitory effect in the pylorus was reversed by L-
arginine. Conclusions These findings suggest that the cholinergic/adrenergic and NANC
inhibitory nerves play important roles in regulating contraction and relaxation of the human …
Results
Cholinergic nerves were mainly involved in the regulation of enteric nerve responses to EFS in the basal condition of the study, and NANC inhibitory nerves acted on human pylorus. L-NNA concentration dependently inhibited the relaxation in response to EFS in the human pylorus, and this inhibitory effect in the pylorus was reversed by L-arginine.
Conclusions
These findings suggest that the cholinergic/adrenergic and NANC inhibitory nerves play important roles in regulating contraction and relaxation of the human pylorus, and that NO plays an important role as a neurotransmitter in NANC inhibitory nerves of the human pylorus.
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