Patients with untreated hypertension have been shown to be resistant to insulin-stimulated
glucose uptake and both hyperinsulinemic and hypertriglyceridemic when compared with
matched control groups with normal blood pressure. In addition, insulin resistance,
hyperinsulinemia, and hypertriglyceridemia have been demonstrated in rat models of
hypertension, including spontaneously hypertensive rats and Sprague-Dawley rats fed a
fructose-enriched diet, and the defect in insulin-stimulated glucose uptake in these …